Welcome to FTProd

This is FTProd, a plugin for VMD designed to characterize and identify cross-structural 'hotspots' in proteins. The program FTMAP identifies these druggable hot spots by docking a series of small molecular probes onto the protein surfaces. FTProd combines these output structures, clusters them, and displays them visually for easy comparison.

Proteins are dynamic entities

To merely consider a single, frozen structure of a protein, important information may be neglected. Proteins constantly move, change shape, and mutate. FTProd allows a researcher to consider this fluctuations in the analysis and prediction of ligand-binding hot spots.

Features

• Graphical user interface (GUI)
• Several clustering methods available
• Useful for comparing protein strains, an NMR ensemble, or simulation snapshots

Getting Started

• Download This package includes relevant FTProd scripts and programs, as well as installation instructions.
• Tutorial Learn how to use FTProd with this short step-by-step tutorial.

Useful Links

FTProd requires the molecular viewing program VMD to run. It also requires output from the program FTMAP.

• Download VMD
• FTMAP server